Welcome to Sergi Castellano's home page.

I am biologist working in computational and evolutionary biology, with particular interest in the application of these fields to selenium biology.

I got my PhD in Bioinformatics in Roderic Guigó's group at the Universitat Pompeu Fabra and the Centre de Regulació Genòmica in Barcelona. Followed by short research stays with Marla J. Berry at the University of Hawaii and Andrew G. Clark at Cornell University in New York. In these labs, I worked on the computational identification and annotation of selenoproteins and population genetics/molecular approaches to their evolution.

I am currently in Sean R. Eddy's lab at the Janelia Farm Research Campus of the Howard Hughes Medical Institute in Virginia. I work on probabilistic algorithms for sequence analysis

Please, drop me a line: castellanos at janelia.hhmi.org

Submitted

S Castellano*, AM Andrés*, E Bosch, M Bayes, R Guigó and AG Clark The unique role of selenocysteine in protein activity exposed in vertebrate selenoproteomes Submitted A Merlos-Suarez, M Buchholz, A Heidenblut, J Luttges, S Castellano, T Gress, S Hahn and FX Real A global analysis of the human pancreatic transcriptome defines a distinct gene expression profile in ductal cells Submitted *Equal contribution

In press

JF Abril, S Castellano and R Guigó Comparative gene prediction in Comparative Gene Prediction in Comparative Genomics: A Guide to the Analysis of Eukaryotic Genomes M.D. Adams (Ed.). Humana Press. In press

Publications

S Castellano, VN Gladyshev, R Guigó and MJ Berry SelenoDB 1.0: a database of selenoprotein genes, proteins and SECIS elements Nucleic Acids Research, 36, D339-D343 (2008)   [Database] S Castellano Little biological and statistical support for hundreds of selenoproteins in mouse pseudo-messenger RNAs PLoS Genetics, eLetters (2006)   [A critical assessment of computational experiments in PLoS Genetics, 2, e3 (2006)] S Castellano, AV Lobanov, C Chapple, S Novoselov, M Albrecht, D Hua, A Lescure, T Lengauer, A Krol, VN Gladyshev and R Guigó Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family Proceedings of the National Academy of Sciences USA, 102, 16188-16193 (2005)   [Commentary in PNAS] K Taskov, C Chapple, GV Kryukov, S Castellano, AV Lobanov, KV Korotkov, R Guigó and VN Gladyshev Nematode selenoproteome: the use of selenocysteine insertion system to decode one codon in an animal genome? Nucleic Acids Research, 33, 2227-2238 (2005) International Chicken Genome Sequencing Consortium Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution Nature, 432, 695-716 (2004)   [Commentary in Nature] International Tetraodon Genome Sequencing Consortium Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype Nature, 431, 946-957 (2004)   [Commentary in Nature]   [F1000 evaluation] S Castellano Towards the characterization of the eukaryotic selenoproteome: a computational approach PhD thesis, July 2004   [Cover PDF file]   [LaTeX template Tar file] S Castellano, SV Novoselov, GV Kryukov, A Lescure, E Blanco, A Krol, VN Gladyshev and R Guigó Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution EMBO reports, 5, 71-77 (2004)   [Datasets]   [Commentary in EMBO]   [F1000 evaluation] GV Kryukov, S Castellano, SV Novoselov, AV Lobanov, O Zehtab, R Guigó and VN Gladyshev Characterization of mammalian selenoproteomes Science, 300, 1439-1443 (2003)   [Datasets] S Castellano, N Morozova, M Morey, MJ Berry, F Serras, M Corominas and R Guigó in silico identification of novel selenoproteins in the Drosophila melanogaster genome EMBO reports, 2, 697-702 (2001)   [Datasets]

Last updated: May 2008