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Welcome to the Eddy/Rivas lab at the Janelia Farm Research Campus of the Howard Hughes Medical Institute. Research in the lab currently focuses on computational genome sequence analysis. We use probabilistic modeling techniques to develop new algorithms to find features in DNA, RNA, and protein sequences. One of our primary interests is in identifying novel structural and catalytic RNAs, and another is to recognize remote protein sequence homologies.
We moved to Janelia Farm in 2006, in part because we see neurobiology as one of the great remaining frontiers of basic biology. Computational genomic analysis will help study the fundamental molecular components that neurons and neural circuits are made of. Our colleagues at the Farm are also quickly getting us interested in algorithms for high-throughput data analysis in neurosciences, as well as other topics in experimental and computational neuroscience.
[More about our current research interests...]
A Probabilistic Model of Local Sequence Alignment that Simplifies Statistical Significance Estimation.
S. R. Eddy.
manuscript submitted, 2008.
[preprint]
Supplementary material: [Notes and C source code (.tgz)]
The Pfam Protein Families Database.
R. D. Finn, J. Tate, J. Mistry, P. C. Coggill, S. J. Sammut, H.-R. Hotz, G. Ceric, K. Forslund, S. R. Eddy, E. L. L. Sonnhammer, A. Bateman.
Nucleic Acids Research, 36:D281-D288, 2008.
[abstract] [preprint]
Database access: [Pfam]
[More about our publications...]
HMMER [website]
Hidden Markov models for sequence profile analysis.
Infernal [website]
RNA structure analysis using covariance models.
[More about software we make available...]
Pfam [website]
Database of protein family alignments and hidden Markov models.
Rfam [website]
The Rfam database of RNA alignments, consensus secondary structures, and profile SCFGs.
[More about databases and servers we make available...]
HHMI Janelia Farm Research Campus
19700 Helix Drive
Ashburn, VA 20147, USA
Phone: 571.209.4000 [this is the general Janelia operator number, not an office]
[More about people in the lab and their contact info...]
